Home Health Study links early infections to future risk of cardiovascular disease

Study links early infections to future risk of cardiovascular disease


A study led by Melbourne found a link between infections at an early age and the risk of cardiovascular disease in adulthood, opening up opportunities for targeted intervention.

A study led by c Murdoch Children’s Research Institute (MCRI) found that elevated markers of inflammation and changes in metabolism – the way body cells process food into energy – are seen in infants prone to infections, reminiscent of those in adults at risk for cardiovascular disease.

The results show that exposure to cumulative infections in infants may predispose adults to a higher risk of heart disease, obesity, stroke and type 2 diabetes, said researcher Dr Toby Mansell of MCRI.

“We have found that the risk of cardiovascular disease in adults can increase from an early age,” he said.

“We know that babies are prone to infections. It causes inflammation, a key cardiometabolic risk factor, but the relationship between infection, inflammation, and metabolic profiles in early childhood has remained insufficiently studied prior to this study. ”

The study involved 555 infants from the Barwon Infant Study, a joint project between Barwon Health, Murdoch Children’s University and Dickin University, in which infant infections were monitored for 12 months.

The study found that high levels of infection in infants under 12 months of age were associated with increased markers of inflammation and changes in metabolic profiles that affect how the body processes fats, proteins and sugars.

Murdoch Children’s Professor David Bergner said the infection has been recognized as a potential cause of cardiovascular disease, one of the leading causes of adult death worldwide.

In Australia, cardiovascular disease accounts for a quarter of all deaths, killing one person every 10 minutes. More than 4 million Australians have cardiovascular disease, and someone is hospitalized every minute with the disease.

Professor Burgner said the study opens up opportunities for early preventive measures such as identifying the types of infection and children at greatest risk, as well as how those risks can be offset by simple interventions.

“Targeted actions may include promoting breastfeeding, providing timely vaccinations and supporting families so they can keep children at home when they are sick from infection,” he said.

Researchers from the Royal Children’s Hospital, the University of Melbourne, the Baker Heart and Diabetes Institute, the Flora Institute of Neurology and Mental Health, Dickin University, Radbud University Medical Center in the Netherlands, the University of Queensland, the University of Queensland and Barvones Health and Barvones Health. to study.

Image: © stock.adobe.com/au/Bonn


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